Long - term measurement of muscle denervation and locomotor 1 behavior in individual wild type and ALS model mice
نویسنده
چکیده
Long-term measurement of muscle denervation and locomotor 1 behavior in individual wild type and ALS model mice 2 3 Turgay Akay 4 Dept. of Neurological Surgery 5 Center for Motor Neuron Biology and Disease 6 New York, NY, USA 7 8 9 Running head: In vivo assessment of muscle denervation in ALS 10 11 Contact information 12 Dept. of Neurological Surgery 13 Center for Motor Neuron Biology and Disease 14 630 West 168 street, P&S Building 5-447 15 New York, NY 10032, USA 16 17 email: [email protected] 18 phone: 1-212-305-9931 19 fax: 1-212-305-5544 20 21 22 23 24 Articles in PresS. J Neurophysiol (October 30, 2013). doi:10.1152/jn.00507.2013
منابع مشابه
Innovative Methodology Long-term measurement of muscle denervation and locomotor behavior in individual wild-type and ALS model mice
Akay T. Long-term measurement of muscle denervation and locomotor behavior in individual wild-type and ALS model mice. J Neurophysiol 111: 694–703, 2014. First published October 30, 2013; doi:10.1152/jn.00507.2013.—The increasing number of mouse models of human degenerative and injury-related diseases that affect motor behavior raises the importance of in vivo methodologies allowing measurement...
متن کاملLong-term measurement of muscle denervation and locomotor behavior in individual wild-type and ALS model mice.
The increasing number of mouse models of human degenerative and injury-related diseases that affect motor behavior raises the importance of in vivo methodologies allowing measurement of physiological and behavioral changes over an extended period of time in individual animals. A method that provides long-term measurements of muscle denervation and its behavioral consequences in individual mice ...
متن کاملP 45: De- and Remyelination Affect Cognitive and Locomotor Abilities in Mice
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammatory and neurodegenerative processes. One of its pathophysiological hallmarks is demyelination, a consequence of oligodendroglial cell death leading supply shortfall and missing electrical insulation to axons. Demyelination induced consequences on neuronal network activity and subsequen...
متن کاملAmyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset disease characterized by upper and lower motor neuron degeneration, muscle wasting and paralysis. Growing evidence suggests a link between changes in lipid metabolism and ALS. Here, we used UPLC/TOF-MS to survey the lipidome in SOD1(G86R) mice, a model of ALS. Significant changes in lipid expression were evident in spinal cord and skele...
متن کاملDihydrotestosterone Ameliorates Degeneration in Muscle, Axons and Motoneurons and Improves Motor Function in Amyotrophic Lateral Sclerosis Model Mice
Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by a progressive loss of motoneurons. The clinical symptoms include skeletal muscle weakness and atrophy, which impairs motor performance and eventually leads to respiratory failure. We tested whether dihydrotestosterone (DHT), which has both anabolic effects on muscle and neuroprotective effects on axons and motoneurons, can...
متن کامل